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KMID : 0606920220300060576
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Biomolecules & Therapeutics
2022 Volume.30 No. 6 p.576 ~ p.584
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Synthetic Homoisoflavane Derivatives of Cremastranone Suppress Growth of Colorectal Cancer Cells through Cell Cycle Arrest and Induction of Apoptosis
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Shin Ha-Eun
Lee Seul
Choi Ye-Ram
Park Sang-Kyu
Kwon Sang-Il
Choi Jun-Kyu
Seo Seung-Yong
Lee Young-Hee
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Abstract
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Colorectal cancer is diagnosed as the third most prevalent cancer; thus, effective therapeutic agents are urgently required. In this study, we synthesized six homoisoflavane derivatives of cremastranone and investigated their cytotoxic effects on the human colorectal cancer cell lines HCT116 and LoVo. We further examined the related mechanisms of action using two of the potent compounds, SH-19027 and SHA-035. They substantially reduced the cell viability and proliferation in a dose-dependent manner. Treatment with SH-19027 and SHA-035 induced cell cycle arrest at the G2/M phase and increased expression of p21 both of which are implicated in cell cycle control. In addition, the apoptotic cell population and apoptosis-associated marker expression were accordingly increased. These results suggest that the synthesized cremastranone derivatives have anticancer effects through the suppression of cell proliferation and induction of apoptosis. Therefore, the synthesized cremastranone derivatives could be applied as novel therapeutic agents against colorectal cancer.
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KEYWORD
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Anticancer effect, Homoisoflavane derivatives of cremastranone, Cell cycle, Apoptosis, Colorectal cancer
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